Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially
because of its immunomodulatory role. Notwithstanding, glutamine plays several other biological
functions, such as cell proliferation, energy production, glycogenesis, ammonia buffering, maintenance
of the acid-base balance, among others. Thus, this amino acid began to be investigated in sports
nutrition beyond its effect on the immune system, attributing to glutamine various properties, such as
an anti-fatigue role. Considering that the ergogenic potential of this amino acid is still not completely
known, this review aimed to address the main properties by which glutamine could delay fatigue, as
well as the effects of glutamine supplementation, alone or associated with other nutrients, on fatigue
markers and performance in the context of physical exercise. PubMed database was selected to
examine the literature, using the keywords combination “glutamine” and “fatigue”. Fifty-five
studies met the inclusion criteria and were evaluated in this integrative literature review. Most of
the studies evaluated observed that glutamine supplementation improved some fatigue markers,
such as increased glycogen synthesis and reduced ammonia accumulation, but this intervention did
not increase physical performance. Thus, despite improving some fatigue parameters, glutamine
supplementation seems to have limited effects on performance.

In order to see more detailed data and the results of the scientific research, consults the article “Glutamine as an Anti Fatigue Amino Acid in Sports Nutrition” written by Audrey Yule Coqueiro, Marcelo Macedo Rogero and Julio Tirapegui.